Health - TransPharm

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Introduction

The HORIZON-RIA with proposal number: 101057816 “Transforming into a sustainable European pharmaceutical sector” is a Horizon Europe Framework Programme (HORIZON) that will contribute to a Europe, that is self-sufficient by reducing dependence on API production in third countries; making the EU healthcare industry more competitive, sustainable and reliable, ensuring timely supply of essential medicines from particularly complex or critical supply and distribution chains and positioning EU as a leader in innovative technologies. Therefore, it brings together leading researcher from 5 universities and 6 associated non-academic partner organisations, including industrial partners, a government agency, a private, not-for-profit think tank and a SME focused on consultancy. The project is coordinated by prof. Christian Stevens (Ghent University, Belgium) and will run from June 2022 until May 2026 (48M).

These are the 11 partners that are involved into this project:

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Project description

TransPharm two-track approach focusses on the one hand on the compounds itself by identifying greener and more sustainable-by-design Active Pharmaceutical Ingredients (APIs) and on the other hand reducing the environmental impact and resilience of the manufacturing process by optimizing the synthesis route of new APIs in continuous flow and by proposing greener alternative solvents. The aim of the project is to (i) analyse and predict flow behaviour and environmental biodegradability of APIs and their synthesis pathways; (ii) identify greener and more sustainable alternatives to pharmaceutical products / APIs of concern; (iii) reduce the footprint and create important shortcuts in synthetic schemes of APIs; and (iv) assess the sustainability of pharmaceuticals over their entire life cycle. To reach the envisaged aims, the project will deliver four toolboxes (consisting of digital tools and guidelines) for the development of greener pharmaceutical products and APIs. These toolboxes will be used to (v) assess the potential to move towards the transition to greener, more agile pharmaceutical production. In addition, TransPharm will elaborate on the business case for sustainable pharmaceutical products or APIs and what is needed to bring them to the market. The project will also make sure that (vi) key project results and knowledge are properly transferred towards targeted stakeholders. TransPharm’s outcome contribute to a Europe, that is self-sufficient by reducing dependence on API production in third countries; making the EU healthcare industry more competitive, sustainable and reliable, ensuring timely supply of essential medicines from particularly complex or critical supply and distribution chains and positioning EU as a leader in innovative technologies.

Objectives

These are the 6 objectives of TransPharm:

  • Objective 1: optimize the use of existing and new data for greening drug synthesis and development
  • Objective 2: identify greener and more sustainable-by-design APIs as a proof of concept
  • Objective 3: reduce the inputs and outputs of API synthesis through introducing shortcuts in API synthesis schemes
  • Objective 4: provide new methodologies to assess the sustainability of pharmaceuticals over their entire life cycle
  • Objective 5: provide a perspective on future possibilities regarding actual use of greener pharmaceuticals
  • Objective 6: transfer the knowledge to concerned stakeholders

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Role of Ghent University

Ghent University coordinates the project and will be involved in all the work packages of the project.

Website

to be announced

Contact

Department of Green Chemistry and Technology at the Faculty of Bioscience Engineering (Ghent University)
Prof. Christian Stevens
Phone number: +32 9 264 59 57
E-mail   

Prof. Jo Dewulf
Phone number: +32 9 264 59 49
E-mail     

Department of Materials, Textiles and Chemical Engineering
Prof. Kevin Van Geem
Phone number: +32 9 264 55 97
e-mail  

Department of Animal Sciences and Aquatic Ecology
Prof. Karel De Schamphelaere
Phone number: +32 9 264 37 64
e-mail